Everything You Need to Know About Aspartic Acid

Written by Ben Bunting: BA, PGCert. (Sport & Exercise Nutrition) // British Army Physical Training Instructor // S&C Coach.


Aspartic acid is a non-essential amino acid that is made by the body and is a precursor to other amino acids and nucleotides.

It helps send chemical signals throughout the nervous system, aids in energy production. Other benefits may include boosting the immune system, protecting against toxins, and help with chronic fatigue, if not testosterone and performance.

Aspartic acid is found in proteins, multivitamins, and food supplements.

L-aspartic acid

L-aspartic acid is a non-essential amino acid found in proteins. It is a key component of the energy cycle and is also important for brain and neural health.

It helps in the production of (adenosine triphosphate) ATP and plays a role in the ornithine cycle. It helps in absorbing calcium and is beneficial in regulating the nitrogen balance in the body. It also helps in the production of enzymes and antibodies. 

It also helps in the production of glutamine, which controls the activity of the cells. You can get this amino acid from foods such as almonds, bananas, peanuts, chicken, and eggs. You can also find it in meat and fish, such as sausage meat and oysters.

Fortunately, most people do not have a deficiency in aspartic acid. However, if you are eating a low-protein diet or are suffering from an illness that requires a higher level of aspartic acid, you could be at risk of a deficiency.

Aspartic acid deficiency can slow your metabolism and cause fatigue. Therefore, you may want to take supplements containing this amino acid. In addition to improving energy levels, these supplements can help remove toxins from your body, as well as excess ammonia.

Besides being a natural metabolite, aspartic acid also participates in the urea cycle and gluconeogenesis process. Moreover, aspartic acid helps carry reducing equivalents via the malate-aspartate shuttle.

In addition, aspartate is essential for proper brain development. It also affects the NMDA receptor, which is essential for memory and cognitive functions. In addition, aspartic acid helps the body create other amino acids and helps prevent deficiency.

When ingested, L-aspartic acid is incorporated into the proteins produced in the body. As a result, it encourages the production of antibodies that support the body's immune system.

D-aspartic acid, on the other hand, is not used to synthesize proteins. It is found in the pituitary gland and the testes, where it plays an important role in regulating testosterone levels. D-aspartic acid is also important for the regulation of LH, which promotes the production of sperm in men.

It's important to remember that aspartic acid is not considered an essential amino acid, and adequate protein intake will provide all the amino acids your body needs.

But it's important to remember that while aspartic acid is a vital component of healthy muscle building, it's also crucial to regulate testosterone levels, therefore ensure that your protein intake is adequate for your needs. 

D-aspartic acid

D-aspartic acid is a very small organic molecule that plays an important role in the body's metabolism.

It is closely related to the amino acid asparagine and is found naturally in asparagus plants. It has been associated with several male health issues and is widely availble as a supplement in many forms. 

D-aspartic acid helps the brain develop and communicates nerves. It also helps produce various hormones.

However, despite its many beneficial health benefits, there are still many questions surrounding its safety and effectiveness.

Although the FDA has not yet approved D-Aspartic acid for medical use, regardless of its purported use for cognitive health because it lacks the solid 'gold standard' clinical research to back up its claims. 

D-aspartic acid is often marketed as an amino acid that can increase testosterone levels.

Although this is true, some studies have found no difference between those taking D-aspartic acid and those taking a placebo.

That said, many studies of various substances do result in contradictory outcomes, but this may have a lot to do with the study procedures and demographic of people used in the research.

This amino acid is not essential for the human body and can be produced naturally by our bodies but the body isn't able to produce enough to see some of the performance gains observed in some studies using supplemental d-aspartic acid.

While D-aspartic acid supplements have demonstrated to increase strength and power in some demographics, it is important to be aware that these results aren't always achievable amongst all sections of the population and appear to benefit trained athletes. 

There is a recommended daily dosage of 3 grams and too much can have no effect at all, so it is a fine balance and one that needs to be taken with care.  

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Aspartic Acid Structure

When constructing proteins, aspartic acid is one of the most important amino acids. The structure of aspartic acid consists of a carboxylic acid and an amino group.

This gives it two different functions in the body: as an amino acid and a carboxylic acid. This is the reason why it is used in protein biosynthesis. The amino group is what allows the protein to bind to a receptor.

Aspartic acid is a polar I+ amino acid that contains two carboxyl groups and one additional methylene group. The carboxyl group is ionized at physiological pH, and this is where it gets its name.

This acid shares its subcategory with glutamic acid. This article will discuss the basic structure of aspartic acid and its relationship to other amino acids. It is essential to understand the structure of aspartic acid to make sense of its chemical properties.

Aspartic acid has two carboxyl groups, both of which are negatively charged. These groups can form dipole interactions with water and form ionic bonds with metal ions.

This concept is important in understanding the solubility of amino acids in water. Moreover, aspartic acid has two carboxyl groups and an isoelectric point of 2.77. This neutral pH value is equal to half of the pKa of its non-polar form.

The main difference between aspartic acid and cysteine is that cysteine has a longer side chain, and is linked to aspartic acid by a disulfide bridge. In the former case, the side chain is a loop that forms inside a peptide chain.

Aspartic acid structure differs from that of cysteine, which is often listed separately in amino acids lists. In addition, cystine has an R-group attached to its a-amine, which allows it to link to other amino acids.

What Does Aspartic Acid Do For Your Body?

Aspartic acid is important for maintaining the health of your brain and nervous system. It helps regulate the release of neurochemicals and hormones and aids the absorption of nutrients from the blood.

It has a critical role in the neuroendocrine system and helps produce neurotransmitters. It also promotes cellular activity by assisting the synthesis of other amino acids.

It has also been shown to be beneficial for your mental health by preventing depression, Alzheimer's disease, and dementia.

Aspartic acid is used as a building block of proteins and is one of 20 proteinogenic amino acids.

It is derived from food sources but is also produced in the liver. It is a critical part of the metabolism, plays a role in brain development, and protects the body from toxins. In addition, aspartic acid is an important component in the process of chelating minerals. 

It is produced in the body in two different forms. One forms aspartic acid, known as L-aspartic acid, serves as a building block for proteins.

The other form, D-aspartic acid, is produced in the endocrine system. It is present in the testes, the adrenal gland, and the pituitary gland.

Supplements containing L-aspartic acid are available in powder form. Many athletes and sports people take these supplements and some may gain optimal results, although as mentioned, some studies have conflicting results.

For those studies that saw a positive benefit among their participants doses were in the region of 2-3 grams daily. If you are an athlete with a team of sports sceintists and nutritionists available, ensure you speak to them about taking it and maintain transparency.

Aspartic acid supplementation may improve female fertility. In a recent study of 20 women undergoing IVF, researchers discovered that aspartic acid supplements were associated with higher quality oocytes.

The high levels of D-aspartic acid found in the follicular fluid around the developing egg could also contribute to increased fertility rates.  

Can D-Aspartic Acid Cause Gynecomastia?

D-aspartic acid (DAA) is a physiological amino acid that has produced mixed results among the few available studies. It is found in the pituitary gland and testes where it regulates the release of LH and the synthesis of testosterone. 

One of the most important facts about gynecomastia (gyno) is that it can affect each breast differently. It can cause painful breasts and even an unpleasant discharge from the nipples.

In some cases, the condition may persist for more than two years. However, it is important to note that it is a symptom of an underlying endocrine disorder and must be diagnosed by a medical professional.

Another factor that can cause gynecomastia tissue is a mutation of the androgen receptor (AR). This gene mutation causes a loss of function in the AR and is known as A721T.

If the patient had no family history of gynecomastia or infertility it would suggest that the mutation is a de novo mutation.

One may think that if DAA has a role in the synthesis of testosterone it can potentially cause gyno, however, there are no reliable studies or research available to suggest that DAA can cause gyno.

D-Aspartic Acid and Erectile Dysfunction

If you're suffering from erectile dysfunction, it's likely that you've heard of d-aspartic acid. 

Those who think low testosterone is the sole cause of erectile dysfunction may suggest that DAA will increase testosterone levels and therefore treat erectile dysfunction.

However, we know that there are mixed results regarding DAA's ability to increase testosterone. Therefore we cannot be certain of the results accross a broad section of the population.

In addition, there are no studies from reputable sources that has a direct proven link between erectile dysfunction being teated by the use of DAA supplementation. 

It is important to remember that erectile dysfunction can be the result of many different aspects to a persons physiological and mental health. Testosterone levels can be part of the cause, but not necessarily the sole cause. 

Does D-Aspartic Acid Increase Sperm Count?

D-aspartic acid has been implicated in male fertility due to its capacity to increase the synthesis of testosterone and release of progesterone from the gonads. 

A recent study reported that the presence of D-aspartic acid in human seminal plasma and spermatozoa may be associated with male fertility. 

D-aspartic acid has been shown to enhance the morphology of sperm, which affects the sperm quality. Men with a high level of D-aspartic acid have higher sperm motility and more mature sperm.

Men who exercise regularly have lower risk of reducing testosterone levels. Regardless of the source of D-aspartic acid, men should continue to prioritize physical activity as an important part of a healthy lifestyle.

In addition to D-aspartic acid, men should also consume vitamin C, zinc, and L-carnitine.  

The Sp2 Hybridization of Aspartic Acid

Aspartic acid is a dipeptide that has a pH of between 1.88 and 3.65. It is also known by the IUPAC abbreviation 2-Aminobutanoic acid.

The molecule has four carbon atoms, two of which are carbonyl carbon atoms of the carboxyl group. Both of these are sp2 hybridized. The molecule is trigonal planar, with a 120o bond angle.

Aspartic acid is an important building block of proteins and is found in a wide variety of foods. It differs from other amino acids in that it contains two functional groups, one of which is a carboxyl group (COOH) and the other is an amine group (NH2) with a side chain of -CH2-COOH.

Aspartic acid is the most acidic of all the amino acids. Aspartic acid is synthesized from oxaloacetate. It is an important part of the gluconeogenesis process and in the production of inosine. It is a neuromediator, although less potent than glutamate.

The difference between aspartic acid and glutamine is reflected in the pKa values of each compound. The lower pKa value of aspartic acid reflects that the ammonium group in it is closer to the acidic site than the hydrogen atom of glutamine.

Both aspartic acid and glutamine have identical pKa values, but aspartic acid is closer to the pH of a neutral solution, its pKa value is lower.

Titration Curve For Aspartic Acids

The titration curve for aspartic acids is a graph that shows the change in pH as a substance is added to a solution. This graph can be read at any point along the curve to determine the pH of the solution.

The graph begins with a low pH and increases sharply when the hydrogen ions are neutralized. Once the acid becomes basic, the graph leveled out and the pH was the same as before the addition of the acid. Most titration curves follow a similar pattern.

The titration curve for aspartic acids shows two distinct regions of buffering power. The first region of the curve is relatively flat and extends for about a pH unit on either side of the first p K a.

It is an excellent buffer near pH 2.34 but not as effective near pH 9.60, which is the pH of blood. Therefore, glycine is a poor buffer at this pH level.

The titration curves for amino acids are very complex. This is because the amino acids have different side chain chemistry. For instance, glutamine is basic while histidine is acidic.

Titration curves for aspartic acid will be different than those for glutamic acid because glutamine does not have an R-group. Hence, the titration curve for aspartic acid is not the same as that for glutamine, lysine, or histidine.


The benefits of aspartic acid supplements have been studied for over thirty years.

Some studies have concluded that aspartic acid supplements don't increase testosterone levels, whereas other studies have. The issue may come in the form of the participants, makig it hard to find an answer for the average male.

In addition, there are some studies which have shown that aspartic acid can increase sperm motility and production. The results of these studies also showed an increase in the number of sperms produced in men who took aspartic acid supplements.

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