Why Does Testosterone Not Affect All Cells in the Body?

by Benjamin Bunting BA(Hons) PGCert

Ben Bunting BA(Hons) PGCert Sports and Exercise Nutrition Level 2 Strength and Conditioning CoachWritten by Ben Bunting: BA, PGCert. (Sport & Exercise Nutrition) // British Army Physical Training Instructor // S&C Coach.


In this article, we will examine the role of the Sertoli cells in the body and the Non-classical kinase activation pathway in testosterone production. It also discusses the role of Growth hormones and Sertoli cells in the production of testosterone. To conclude, we can say that the testosterone hormone has a dual effect in the body, regulating both growth hormones and metabolism.

Non-classical kinase activation pathway

This study suggests that despite the fact that classical and nonclassical kinase activation pathways are both active, the classical pathway affects only one type of cell. Inhibition of the nonclassical pathway blocks spermatogenesis in vivo. However, the classical pathway remains functional in the body. However, the findings of the study are still preliminary and further studies are needed to determine whether nonclassical T signaling is essential for sperm maturation and male fertility.

Testosterone activates both phosphorylated and total ERK, but not all cells in the body. Nevertheless, the nonclassical pathway was confirmed in Sertoli cells in vivo. Moreover, a dominant-negative form of the AR suppresses the expression of PSA-luciferase and does not affect testosterone-mediated increases in ERK phosphorylation.

Sertoli cells

While scientists have known for 70 years that testosterone is essential for male fertility, they still don't understand the exact mechanisms by which testosterone works to regulate different cells in the body. For instance, they don't know whether Sertoli cells contain genes that are regulated by testosterone, or whether they lack the gene. The results of these studies are still preliminary, but they will hopefully provide the intellectual resources needed to develop more effective treatments for sexual dysfunction and contraception.

While there is no conclusive answer to the question, scientists do know that men's immune systems are not as robust as women's. This is because their bodies are unable to respond to vaccinations as well as women's. Men's blood is more prone to inflammation, while women's response is stronger. This may be due to differences in hormone levels between men and women. 

Growth hormones

Growth hormone is a protein that regulates glucose levels in the blood. It stimulates the liver to produce more glucose and suppresses the uptake of insulin. However, it has been linked to diabetes due to its effect on the liver. There are two kinds of growth hormone receptors: one that binds outside the cell, and one that binds inside the cell. Growth hormone binds to both sites simultaneously, resulting in direct effects on the target cells. One of these receptors is found on fat cells, and growth hormones increase the fat cell's metabolism and suppress its ability to accumulate circulating lipids.

Earlier, growth hormone treatment lasted until the end of growth. It has also been linked to increased energy levels. In addition, growth hormone helps reduce body fat, thereby contributing to muscle and bone development. Hence, some growth hormone specialists may recommend lifelong treatment for patients with growth hormone deficiency. Growing research has shown that 30-50% of adults with growth hormone deficiency experience fatigue, even if they have a normal body weight.

military muscle testosterone booster banner


Testosterone is a primary androgen synthesized from cholesterol and other precursors in the testicles. Its biological action depends on its interaction with other anabolic signaling pathways. Testosterone's biological effects depend on its ligand, the IGFBP-1 receptor, and the physiological stress experienced. In addition, the KISS1 gene encodes a peptide known as kisspeptin. Kisspeptin is a 54-amino-acid peptide that is released from neurons in the arcuate nucleus and anteroventral periventricular nucleus.

While testosterone is required for male fertility, its action is largely unknown. Only recently have molecular mechanisms for its action been identified. Several genes regulated by testosterone, but not all of them, have been identified in Sertoli cells. Testosterone has a direct role in regulating the process of spermatogenesis. The study of this hormone will provide intellectual resources for the development of therapies and contraceptives.

military muscle test booster