Adderall and Testosterone Replacement Therapy: The Key to Better Focus?

Written by Ben Bunting: BA, PGCert. (Sport & Exercise Nutrition) // British Army Physical Training Instructor // S&C Coach.


Quick Bite:

There is limited evidence on the effectiveness of combining Adderall and TRT. However, the available evidence suggests that Adderall may decrease natural testosterone production, but when combined with TRT, it may help alleviate symptoms of ADHD.

If you are undergoing Testosterone Replacement Therapy (TRT) and are also taking Adderall, it's important to understand the potential interactions and effects.

This article will cover the side effects, physical and psychological benefits, and the possible risks of these drugs.

Keep reading to learn more. This article also provides information on the drug interactions between testosterone and adderall.

Adderall Explained

Adderall is a common stimulant used to treat Attention-Deficit Hyperactivity Disorder (ADHD).

It helps to improve alertness, focus, and concentration, but there are a few things you should know before you begin taking this medication. Adderall is a blend of amphetamine and dextroamphetamine.

According to the 2022 National Survey on Drug Use and Health, 1.5 percent of people aged 12 or older (or 4.3 millions) misused prescription stimulants during the past year. 

College Students may be more likely to misuse Adderall in order to "get ahead" or improve their grades.

How Adderall Works in the Body

Adderall is a combination of amphetamine and dextroamphetamine used to treat attention deficit hyperactivity disorder (ADHD), as well as narcolepsy.

Adderall contains amphetamines and dextroamphetamines, two central nervous system stimulants.

They improve focus and reduce impulses by increasing the levels of dopamine and norepinephrine in the brain. 

It does this by increasing neurotransmitters - chemical messengers between cells - which boost dopamine and norepinephrine levels in your brain, helping with concentration, organization, listening ability, emotion regulation, self-motivation and reward systems.

Adderall was approved by the Food and Drug Administration in 1996

Side Effects

Some men experience unwanted side effects of Adderall, which can affect their sexual performance and desire.

However, men can also experience erectile dysfunction caused by other medications that can affect blood vessels in the body.

The potential side effect of Adderall on sex life is a serious concern. This drug can cause a person to become anxious or upset, and can also cause erection difficulties.

You should also be aware that Adderall can interact with alcohol. Alcohol and Adderall work differently in the body, so mixing the two can lead to adverse health effects.

Because alcohol increases heart rate, you may not realize how much alcohol you are drinking.

Then, you may be prone to drinking more than you should, leading to a night of high-risk behavior.

In addition, alcohol and Adderall can affect your heart's functioning and make you more prone to heart disease and alcohol poisoning.

Subscribing to Adderall at doctor-recommended dosages won't make you high, but may cause short-term side effects like loss of appetite and dry mouth.

People with depression or bipolar disorder should not take stimulants such as Adderall because it increases their risk for manic episodes triggered by these drugs.

Stimulants such as Adderall can increase blood pressure, body temperature and heart rate - keeping you awake and active while suppressing appetite.

Unfortunately, however, stimulants like Adderall can have serious ramifications on heart muscles, lungs and vascular systems and lead to irregular heartbeat or sudden death for those suffering from existing cardiovascular issues.

Physical and Psychological Effects

A study of male patients taking Adderall and testosterone replacement therapy found that both drugs significantly increase ratings of positive emotion.

Interestingly, Adderall only affects positively valenced states. Adderall is a highly selective stimulant.

However, it does have some side effects, including dilation of the pupils. Those with glaucoma should not take the drug.

Patients should be monitored for changes in vision, which could indicate a tolerance. If so, the dosage should be increased until symptoms are corrected.

Erectile Dysfunction (ED) Risk

ED is defined as the inability of a man to achieve sufficient penile rigidity for sexual satisfaction.

In men, ED is often the symptom of underlying medical conditions, such as heart disease, kidney dysfunction or low testosterone.

Left untreated, these conditions can significantly limit quality of life and even reduce a man's life expectancy.

In addition, ED negatively affects a man's mental health, his relationship with his partner, and his general well-being. Identifying and treating these underlying medical conditions is crucial to improving men's sexual health and quality of life.

A 2015 study found that amphetamine use was associated with a higher incidence of erectile dysfunction when compared to those who didn't use them.

If you suspect that your Adderall use is contributing to your ED, it is crucial to tell your health care provider as soon as possible.

It is important to tell your doctor right away that you've noticed symptoms of ED, as sudden withdrawal can have a severe physical and psychological impact.

If symptoms persist, contact your doctor as soon as possible, as ED may be a sign of an underlying health problem, including hormonal imbalance, neurological disease, and psychiatric problems.


It is still up for debate whether Adderall and other similar drugs cause significant cardiovascular risk

The most common side effects include hypertension, tachycardia, emotional lability, and increased body temperature, or hyperthermia.

These side effects may not last long, so it is not worth risking your health to try the drug without a doctor's prescription.

Gastrointestinal Issues Caused by Adderall

Adderall can slow down the muscles in your digestive tract, which could lead to constipation and abdominal pain. Adderall can also cause nausea, diarrhea and the need to urinate frequently.

Adderall can cause anorexia or unintentional weight loss. Malnutrition can cause serious health problems and can have severe side effects.

Adderall can cause sleep problems, which may affect the brain and body. Adderall can also damage kidneys and other organs, leading to potential kidney failure.

Anyone can experience side effects from Adderall abuse, regardless of their age or gender. However, the effects are different for everyone depending on weight, age and gender.

Men and women have different hormones, body fat, and other physiological differences. These differences can affect how Adderall works on an individual basis.

Mood Changes

Adderall can also cause mood swings and behavioral changes. In some cases, stimulant drugs can trigger psychosis or panic attacks, including hallucinations and delusions. 

As the "fight-or-flight" reflex kicks in, heart rate, blood pressure and body temperature can spike.

According to a 2006 study in The New York Times, about 400 patients may experience suicidal or psychotic thoughts when they take ADHD stimulant medication even as prescribed. Risks may increase with recreational or non-medical use.

Does Gender Matter?

The Food and Drug Administration's Adderall information notes that the average weight of women affects the dose administration, as it alters the bioavailability (or availability) of Adderall's amphetamine.

The amount of amphetamine that a woman processed was higher when doses weren't based on her body mass.

When the dose was adjusted the amount of amphetamine was normalized, and the results were similar for both genders.

Two other amphetamines in Adderall, however, were not affected by gender or age.

Some medical studies show that the bioavailability of Adderall to a woman’s body is affected by her menstrual cycle.

This is primarily due to estrogen. Adderall's negative effects are more pronounced during the follicular period, the first 14 days in the menstrual cycles.

Adderall was reported to cause women to feel high, as well as a stronger desire for it and a physical dependence on it.

This may be because the higher levels of estrogen in this period can enhance the effects of amphetamines, as estrogen can trigger dopamine release in the brain.

Women are more susceptible to side effects of Adderall because they process it differently. Side effects include:

  • Increased anxiety levels
  • Sleeping problems or difficulty staying asleep
  • Changes in bowel movement
  • Dry Mouth
  • Headache
  • Dizziness
  • Reduced libido

Adderall Withdrawl

Adderall has been classified as a Schedule II controlled drug, which is the highest level for a drug that has accepted medical uses.

Adderall withdrawal symptoms can occur when chronic Adderall usage is stopped or reduced. Adderall withdrawal may include the following symptoms:

  • Fatigue
  • Cravings
  • Dysphoric mood
  • Nightmares
  • Increased appetite
  • Irritability
  • Psychomotor agitation, or retardation

Adderall misused over a prolonged period can cause brain changes that take time to reverse. The neurotransmitter level will not return to its previous levels before the drug was introduced.

Although Adderall withdrawal is uncomfortable, it rarely causes harm.

Does ADHD Therapy Cause Low Testosterone?

Male hypogonadism does not appear to be a risk with stimulant medications for attention-deficit/hyperactivity disorder (ADHD), however, recent studies have examined this link. 

Although the pathophysiologic link is unclear, it is predicted long-term ADHD stimulant medication use could increase the risk for hypogonadism among post-pubertal men.

An analysis of data found that there is a higher risk of hypogonadism for patients on long term stimulant based ADHD therapy than those men who didn't receive stimulant therapies. 

Does Low Testosterone Effect Focus and Concentration?

Testosterone affects the brain through activation and organizational effects. 

Many relevant studies have been conducted on rodents, and some on humans, yet the causal relationship between testosterone deficiency, behavioral disorders and cognitive abilities remains a controversial issue.

As testosterone levels increase, spatial cognition as well as general cognitive abilities and memory decrease. 

Many clinical studies on postmenopausal and andropause women and men showed that testosterone supplementation improved memory and learning.

Even a 6-week treatment with testosterone improved the spatial and verbal memories of older men.

Furthermore, Alzheimer patients showed positive effects of testosterone on verbal and spatial memory.

 A single dose of testosterone was shown to improve spatial memory in young women. The mechanism of action remains unclear as testosterone is no longer considered a final hormone but rather a precursor. 

Testosterone Replacement Therapy (TRT)

When people hear about testosterone replacement therapy, they generally think of it as a non-essential, elective procedure.

However, low-T is a serious health concern that has significant implications for male sexuality and reproduction.

Low-T is also linked to increased risk for heart disease, diabetes, and visceral fat. Fortunately, there are many reasons for seeking help for this condition. 

Testosterone is an essential hormone, playing an integral part in many aspects of men's health.

As they age, however, testosterone levels decrease over time resulting in decreased energy and muscle mass as well as mood disorders and diminished libido.

Testosterone replacement therapy (TRT) employs different strategies to increase testosterone in the body and alleviate symptoms associated with low testosterone.

Doctors generally prescribe TRT for men diagnosed with hypogonadism - confirmed through blood tests indicating testosterone levels below normal range - who present symptoms associated with their condition, such as fatigue.

A physician will also conduct a complete medical history review in order to ascertain why their testosterone levels have dropped and identify any contributing risk factors that contribute to low levels.

People on testosterone replacement therapy (TRT) should undergo routine office visits and lab tests to monitor their testosterone level and assess for adverse side effects.

Their hematocrit should also be assessed every 3-6 months and then annually in order to ascertain any necessary adjustments to dosage levels.

TRT may be an effective treatment option for various conditions affecting men, but should never replace healthy eating and regular exercise habits.

A healthy lifestyle will also help address potential side effects associated with TRT such as acne breakouts, an enlarged prostate and noncancerous breast growth.

Before opting for TRT alone however a man must explore other potential sources of their symptoms such as fatigue, decreased sexual drive or mood fluctuations before making their decision.

The first and most effective form of testosterone replacement therapy is subdermal testosterone pellets, which are made through high-temperature molding and have been approved for use in the USA by the FDA.

This product is designed for extended, consistent release, and absorption by the nasal mucosa, avoiding first-pass metabolism.

The dosage of testosterone is determined by the patient's age and response to the therapy, but general dosing recommendations are 150 to 450 mg injected subdermally into the hip at three to six-month intervals.

Testosterone pellets are available in generic 12.5, 25, 37, and 50 mg pellets.TRT and adderall infographic

Can TRT Improve Cognitive Function?

Low testosterone can cause a variety of symptoms, including low libido and decreased vitality.

Other symptoms include fatigue, mood swings, anemia, flushes (flushing), erectile dysfunction, decreased muscle mass, increased body visceral fat, ejaculatory problems, and loss in concentration.

Low testosterone levels are also associated with a reduced quality of life, due to symptoms like depression and cognitive impairment.

It is thought that the effect of testosterone on cognitive function and depressive symptoms in hypogonadal males is related to an increase in brain perfusion.

This is supported by the presence of androgen receptors within the brain. Steroid hormones are also believed to play a part in neuronal functions. 

This 2016 study found that TDS patients receiving TRT improved their cognitive function significantly only when mild cognitive impairment existed at baseline.

In other small placebo-controlled studies, the effects of TRT on men with mild cognitive impairment (MCI) or Alzheimer's Disease have been evaluated.

A 2005 randomized controled trial evaluated 32 subjects. This included 17 men who had mild cognitive impairment, and 15 others with Alzheimer's.

Patients who received TRT scored significantly higher than those in the placebo group on tests of spatial memory, verbal memory, and constructional ability at the 6-week check-up.

These results, taken together, suggest that TRT is beneficial for cognitive function.

Testosterone Replacement Therapy Side Effects

However, testosterone therapy is not for everyone. Some men should not undergo the treatment, as it may increase their risk of developing prostate cancer.

Additionally, men with liver or kidney problems may not be candidates for this treatment. 

There are many potential side effects of testosterone replacement therapy, including increased risk of strokes, blood clots, and heart attacks.

In addition, men with a history of breast cancer, severe urinary tract problems, or uncontrolled heart failure should not use testosterone replacement therapy. To avoid these side effects, men should schedule regular follow-up appointments with their doctors. 

This risk is highest during the first six months of treatment and decreases with discontinuation.

In addition, research has shown that men suffering from cardiovascular disease may increase their risk of heart attack after taking testosterone therapy.

If you are considering taking this therapy, it is important to to discuss it in depth with a medical professional.

Testosterone and Adderall Interactions

While there is limited research on the specific interactions between Adderall and Testosterone Replacement Therapy (TRT), it is important to be aware of potential effects and considerations.

Adderall can increase heart rate and blood pressure, and TRT can also have cardiovascular effects.

Therefore, combining the two medications may increase the risk of cardiovascular complications.

Additionally, both Adderall and TRT can affect mood and behavior, so it is important to monitor for any changes in mental health while taking both medications.

It is recommended to consult with a healthcare professional before combining Adderall and TRT to ensure safety and effectiveness.

However, research published by the British Journal of Pharmacology in 1996 did analyze the effects of amphetamine on testosterone secretion.

This study used rats and found that amphetamine had a negative effect on testosterone production.

More recent research published in 2017 found that a stimulant called methylphenidate which is the compound found in similar stimulant drugs to treat a similar condition found that low usage didn't cause much of an effect on testosterone levels. 

Side Effects and Risks of Combining Adderall and TRT

Adderall is widely prescribed to treat Attention Deficit Hyperactivity Disorder, but its use among athletes and those looking for an edge is growing increasingly prevalent.

Although banned for sports participation due to potential performance enhancement risks, many elite athletes continue to use amphetamine-based ADHD medications like Adderall for both medical and nonmedical uses.

Adderall is a combination of amphetamine and dextroamphetamine that is prescribed to treat Attention-Deficit/Hyperactivity Disorder (ADHD) and narcolepsy, and has various side effects which should be noted, including dizziness, dry mouth, nausea, vomiting and insomnia.

Other side effects may include dizziness, dry mouth, nausea vomiting insomnia dizziness constricted pupils constriction which could impede vision as well as decreased serotonin levels which could cause depression and even manic episodes in bipolar patients.

Studies suggest that amphetamine and dextroamphetamine, the drugs found in Adderall, may reduce testosterone production by stopping Leydig cells in the testes from releasing this hormone.

Men taking these medications may experience erectile dysfunction and reduced sexual desire as a result.

It is essential that if you're experiencing erectile dysfunction or other sexual issues while taking Adderall, that you notify your physician as soon as possible.

They can assist in helping to remedy these problems by either altering your dosage on days when you engage in sexual activity, or not taking the medicine shortly beforehand.

Is There a Benefit of Combining TRT with Adderall?

A medical case report published in 2022 details the effects of TRT and Adderall on 3 men.

Drugs such as Adderall that are prescribed to treat ADHD can cause side effects that prevent their use in some patients. 

In one such case, a patient lost his libido whilst under treatment for ADHD. As a result he was offered TRT to help reverse his loss of libido.

The TRT helped with his low libido and low testosterone level, but also help alleviate some of his ADHD symptoms.

It was concluded that lower levels of testosterone may be a contributor of ADHD symptoms, and TRT could provide benefit for these patients.

Therefore, in effect the treatment for ADHD causes low testosterone which may also contribute to the symptoms of ADHD that you are trying to eradicate. As a result combining the ADHD treatment and TRT can help prevent low testosterone and treat ADHD.

Consultation with a Healthcare Professional 

Before combining Adderall and Testosterone Replacement Therapy (TRT), it is crucial to consult with a healthcare professional.

They can provide personalized advice and guidance based on your specific medical history and needs.

Combining these medications can potentially lead to side effects and risks, such as increased heart rate and blood pressure.

Additionally, Adderall and TRT can affect mood and behavior, so monitoring for any changes in mental health is important.

By consulting with a healthcare professional, you can ensure the safety and effectiveness of combining these medications.

Natural Testosterone Boosters to Increase Testosterone

Choosing an effective testosterone booster can be made simple by looking for expert-formulated products that contain scientifically studied ingredients in safe and effective doses.

Additionally, supplements manufactured within facilities with good manufacturing practices (GMP) ensure that the product is free from contaminants and has undergone rigorous testing before reaching consumers.

These supplements also work to boost libido, strength, and performance at both the gym and bedroom.

Furthermore, they assist with burning fat and building muscle mass for a leaner physique - some specifically tailored to athletes while others can bring significant advantages for all men.

Military Muscle is one of the most acclaimed and effective testosterone boosters on the market.

This natural supplement uses a unique combination of nutrients to naturally increase testosterone in your body, supporting lean muscle growth, energy levels and stamina while simultaneously helping break through workout plateaus and achieve personal records in the gym.

Military Muscle testosterone booster contains mucuna pruriens, which works to activate dopamine production in your brain and promote an increase in testosterone production in your body.

Furthermore, aromatase inhibitor urtica dioica prevents testosterone conversion to estrogen; this factor is especially vital since hormonal imbalance can result in reduced sperm count that leads to impotence.

This testosterone booster provides an all-natural formula supported by extensive research, with no reported side effects from clinical trials or past customers. 


Both forms of treatment come with their own set of risks.

Both treatments are not to be taken lightly, and must only be prescribed by a doctor, and whether the two treatments should be combined would be down to the patients individual circumstances and judgement of the medical professional. 

However, it appears there isn't much evidence available regarding combining the two therapies, but what evidence is available does suggest that adderall reduces natural testosterone secretion, but when you add TRT it can alleviate some of the ADHD symptoms. 

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