Can Prednisone Affect Testosterone Levels?

Written by Ben Bunting: BA, PGCert. (Sport & Exercise Nutrition) // British Army Physical Training Instructor // S&C Coach.


Prednisone is one of the most commonly prescribed drugs in the world, but what exactly does it do? 

In this article, we'll explore some of the common concerns that people have with it, including the fact that it can cause a number of unpleasant side effects.


Prednisone is a synthetic hormone that mimics the effect of the hormone cortisone in the body. It's used to treat a variety of illnesses and medical conditions.

Prednisone is an anti-inflammatory drug that is used to reduce swelling and pain caused by an inflammatory condition.

It is best to take the drug in the morning and space it out evenly throughout the day. Patients should follow the instructions on the label of prednisone tablets, and they should not crush or cut them.

Prednisone is used to treat a number of conditions, including asthma, COPD, rheumatoid arthritis, gout, and ulcerative colitis.

It is often used for acute asthma attacks or for flare-ups of conditions such as arthritis or severe allergic reactions. It is also sometimes used as a treatment for symptoms of certain types of cancer.

Prednisone can lower the immune system, increasing the risk of infections. Since this medication can suppress the immune system, patients should avoid contact with sick people and avoid live vaccines.

In addition, patients should discuss the risk of infections with their healthcare provider before starting any new vaccinations, including flu shots or immunizations.

Prednisone is a prescription steroid that is available as an oral tablet, liquid solution, and delayed-release solution.

Both generic and brand-name versions of this drug are available. It works by suppressing the immune system and inhibiting certain chemicals that cause inflammation.

It has anti-inflammatory properties and is often used to treat rheumatoid arthritis and multiple sclerosis. However, it should only be used for short periods.

However, the effects of this drug are not without their risks. As a corticosteroid, prednisone can cause a range of side effects, ranging from mild annoyances to life-threatening organ damage.

Its side effects can also be severe, and they increase with higher dosages and prolonged treatment. 

What is Prednisone Used For?

Prednisone is a corticosteroid that limits the activity of the immune system, especially with regards to inflammation.

Your immune system is responsible for preventing and responding to various diseases, but it can overreact and attack healthy body parts.

Prednisone suppresses this response and can ease symptoms in a variety of rheumatic diseases.

Patients are prescribed prednisone to treat a variety of conditions. These range from conditions affecting the eyes and skin, to those that result in low corticosteroid levels.

It can also be used to treat conditions affecting the thyroid, joints, and blood. Prednisone comes in oral solution or as a dose pack, and the recommended dosage is five to ten milligrams per day.

While prednisone is used for a variety of different conditions, it can interact with many other drugs and increase the risk of unwanted side effects.

As a result, it is important to tell your healthcare provider if you are pregnant or breast-feeding. Also, if you are considering dental or emergency medical treatment, you should inform your doctor of your condition and any possible risks.

Prednisone is an excellent choice for people with autoimmune diseases, and it is also used in the treatment of skin disorders.

For example, it can treat psoriasis, seborrheic dermatitis, exfoliative dermatitis, bullous dermatitis, and edematous conditions.

Additionally, prednisone is used in the treatment of respiratory diseases, and it can prevent the onset of kidney failure.

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Prednisone can lower testosterone levels

Prednisone is a prescription drug that can lower testosterone levels in men. It is used as a treatment for prostate cancer and is associated with side effects such as weight gain and insomnia.

The drug also has potential for reducing bone health. It can be used for short or long periods. This medication also has anti-inflammatory properties. Inflammation is a cause of many health problems, including low testosterone

Prednisone can reduce testosterone levels for men with prostate cancer, but the medication also has side effects.

It can increase blood pressure, cause weight gain, and weaken bones. Men who have had prostate cancer should talk with their doctor before starting the medication.

It can also be used in conjunction with other types of treatment, including chemotherapy and hormone therapy.

Another drug used to treat prostate cancer is Zytiga. It is an oral tablet that contains abiraterone acetate. It lowers testosterone levels in the body, which inhibits the growth of prostate cancer cells

A 1994 study investigating the effects of rheumatoid arthritis (RA) found that those who were prescribed a low dose of prednisone also showed low levels of testosterone and gonadotropin levels.

A further study published in the Respiratory Medicine journal concluded that corticosteroid use did reduce testosterone levels which resulted in dermal thinning, adrenal supression and reduced bone calcium levels.  

Similar results are illustrated in this 1996 study which surmmised that sometimes the treatents used for diseases can cause problems that outweigh original disease.

This 2019 study discovered that prednisone reduced cycling performance, work capacity and altered the testosterone/luteinizing hormone ratio.  

The Fertility and Sterility journal publsihed a report in 1979 regarding women with hyperandrogenism and prednisone used as a treatment. The report concluded that prednisone was likely to reduce plasma testosterone levels.

Does prednisone mess with your other hormones?

The hormone prednisone has many different effects on the body. It affects everything from how the brain processes information to how the body's metabolism functions.

It is most commonly used to treat inflammation. However, it can have some unintended side effects. Here are some things to watch out for and avoid.

One of the most common side effects of prednisone is a disturbance in sleep. Because it affects the hormones that make us feel sleepy and energized, it can make it difficult to fall asleep. It may also make you feel jittery or fatigued.

Another side effect of prednisone is increased risk of certain infections. Users are at risk of acquiring infections from other people and reactivating infections that were previously controlled.

In rare cases, prednisone can cause severe complications, including coma and hypovolemic shock. Additionally, high doses of prednisone may lead to high blood pressure.

For this reason, it is vital to follow your doctor's instructions and follow the prescribed dosage for the maximum time period.

Side Effects

Among its potential side effects, prednisone can cause high blood pressure, a condition known as orthostatic hypotension. It can also cause changes in the skin, such as skin bruising and wrinkles.

Additionally, women taking prednisone should avoid pregnancy as the medication can affect their breast milk. In addition, the long-term use of steroids can also cause bone loss and osteoporosis.

Those who take prednisone may also experience side effects such as ulceration and tendon rupture.

They should consult with their doctor before stopping prednisone, as abrupt discontinuation may lead to serious complications. It is best to follow the prescribed tapering schedule and not to stop taking prednisone abruptly.


The hormone testosterone has several important functions. Low levels of the hormone can lead to a number of health problems, including depression, weight gain, and weakened bones. 

Prednisone is a prescription medication that reduces inflammation. A recent study conducted on 36 men with RA compared their levels to those of 71 men without the disease. 

The researchers found that those who were using prednisone had lower levels of testosterone. Similar results were also found in other studies whereby corticosteroids were being administered. 

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